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3 members of the Guardians of the Globe: Rex Splode, Dupli-Kate, and Shrinking Ray, takes on the Lizard League. The rest of the Guardians are out in space dealing with a Sequid threat. Shrinking Ray and Dupli-Kate dies in the mission (although Dupli-Kate would later reveal that she still had 1 clone saved as backup), and Rex Splode is injured grievously in the mission.
From – Invincible #40