This is the first meeting of Spider-man and Ezekiel Sims. Peter Parker starts to learn that his spider powers aren’t just a product of science, but has ties to something more mystical and grander in design.
This is the point. This is the Five Million Dollar question. I’m about to yank your chain like nobody else ever has before, and nobody ever will again. So listen carefully. Did the radiation enable the spider to give you those powers? Or was the spider trying to give you those powers before the radiation killed it? Which came first? The radiation? Or the power? The chicken or the egg or the power?
From – The Amazing Spider-Man Vol. 2 #30