Spider-man is able to go toe-to-toe with 4 superpowered Hydra agents mimicking Avenger members Captain America, Iron Man, Thor and Hawkeye. Even though Spider-man doesn’t end the fight on his own, I think he can beat these 4 with no problem. The fight ends when the real Avengers came to back up Spider-man.
From – Amazing Spider-man Vol. 1 #523